ILF2 Rabbit Polyclonal Antibody (CAB5882)
- SKU:
- CAB5882
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
Product Name: | ILF2 Rabbit Polyclonal Antibody |
SKU: | CAB5882 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human ILF2 (NP_004506.2). |
Sequence: | MRGD RGRG RGGR FGSR GGPG GGFR PFVP HIPF DFYL CEMA FPRV KPAP DETS FSEA LLKR NQDL APNS AEQA SILS LVTK INNV IDNL IVAP GTFE VQIE EVRQ VGSY KKGT MTTG HNVA DLVV ILKI LPTL EAVA ALGN KVVE SLRA QDPS EVLT MLTN ETGF EISS SDAT VKIL ITTV PPNL RKLD PELH LDIK VLQS ALAA IRHA RWFE ENAS QSTV KVLI RLLK DLRI RFPG FEPL TPWI LDLL GHYA VMNN PTRQ PLAL NVAY RRCL QILA AGLF |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | NF45; PRO3063; ILF2 |
Positive Sample: | MCF7,Raji,A-431,HeLa,Mouse brain,Mouse spleen,Mouse ovary,Mouse thymus,Rat spinal cord |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Nucleus, nucleolus. |
Calculated MW: | 43kDa |
Observed MW: | 50kDa |
The protein encoded by this gene is a transcription factor required for T-cell expression of the interleukin 2 gene. It also binds RNA and is an essential component for encapsidation and protein priming of hepatitis B viral polymerase. The encoded 45 kDa protein (NF45, ILF2) forms a complex with the 90 kDa interleukin enhancer-binding factor 3 (NF90, ILF3), and this complex has been shown to affect the redistribution of nuclear mRNA to the cytoplasm, to repair DNA breaks by nonhomologous end joining, and to negatively regulate the microRNA processing pathway. Knockdown of NF45 or NF90 protein retards cell growth, possibly by inhibition of mRNA stabilization. Alternative splicing results in multiple transcript variants. Related pseudogenes have been found on chromosomes 3 and 14.
Purification Method: | Affinity purification |
Gene ID: | 3608 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |