The IL7R Polyclonal Antibody (CAB1230) is a valuable tool for researchers studying the IL7R protein, a key regulator of immune cell development and function. This antibody, generated in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By binding to the IL7R protein, researchers can accurately detect and analyze its expression in various cell types, making it an essential tool for studies in immunology and cancer research.IL7R, also known as the interleukin-7 receptor, plays a crucial role in the development and survival of T cells, making it a promising target for therapeutic interventions in conditions such as cancer, autoimmune diseases, and immune deficiencies.
Understanding the function and regulation of IL7R is essential for designing effective treatments that modulate immune responses and promote immune system health. The IL7R Polyclonal Antibody provides researchers with a reliable means to investigate the role of IL7R in health and disease, paving the way for advancements in immunotherapy and personalized medicine.
Product Name:
CD127/IL7R Rabbit Polyclonal Antibody
SKU:
CAB1230
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 21-239 of human CD127/IL7R (NP_002176.2).
Cell membrane, Secreted, Single-pass type I membrane protein, Single-pass type I membrane protein.
Calculated MW:
52kDa
Observed MW:
50kDa
The protein encoded by this gene is a receptor for interleukin 7 (IL7). The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukins 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in V(D)J recombination during lymphocyte development. Defects in this gene may be associated with severe combined immunodeficiency (SCID). Alternatively spliced transcript variants have been found.
Purification Method:
Affinity purification
Gene ID:
3575
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using CD127/IL7R antibody (CAB1230) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 180s.
