The IL7 Monoclonal Antibody (CAB22570) is a vital tool for researchers studying IL7, a cytokine that plays a key role in immune system regulation and development. This monoclonal antibody, produced using cutting-edge technology, specifically targets IL7 and has been validated for use in various research applications, including ELISA, Western blot, and immunohistochemistry.IL7 is essential for the development and function of T cells, making it a crucial factor in adaptive immune responses. Dysregulation of IL7 has been linked to various autoimmune diseases, inflammatory disorders, and certain types of cancer, highlighting the importance of studying this cytokine in biomedical research.
The IL7 Monoclonal Antibody allows for precise detection and analysis of IL7 levels in different biological samples, providing valuable insights into the role of IL7 in health and disease. Researchers can confidently rely on the IL7 Monoclonal Antibody (CAB22570) to enhance their studies on immune system function, inflammation, and potential therapeutic targets in various disease settings.
Product Name:
IL7 Monoclonal Antibody
SKU:
CAB22570
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 26-177 of human IL7 (NP_000871.1).
The protein encoded by this gene is a cytokine important for B and T cell development. This cytokine and the hepatocyte growth factor (HGF) form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor. IL7 is found to be a cofactor for V(D)J rearrangement of the T cell receptor beta (TCRB) during early T cell development. This cytokine can be produced locally by intestinal epithelial and epithelial goblet cells, and may serve as a regulatory factor for intestinal mucosal lymphocytes. IL7 plays an essential role in lymphoid cell survival, and in the maintenance of naive and memory T cells. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their presence in normal tissues has not been confirmed. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can be a potent inducer of proinflammatory cytokines and chemokines which may defend against the infection, but may also mediate destructive lung injury. Elevated serum IL7 levels, together with several other circulating cytokines and chemokines, has been found to be associated with the severity of Coronavirus Disease 19 (COVID-19).
Purification Method:
Affinity purification
Gene ID:
3574
Clone Number:
ARC57489
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates, using IL7 antibody (CAB22570) at 1:30000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 120s.
