The IL6R Polyclonal Antibody (CAB1570) is a valuable tool for researchers studying the interleukin-6 receptor (IL6R), a cell surface protein involved in immune response regulation. This rabbit-raised antibody is highly specific for human samples, making it ideal for Western blot applications. By binding to the IL6R protein, this antibody enables accurate detection and analysis in a variety of cell types, making it a key resource for studies in immunology and cancer research.IL6R is a crucial component of the IL6 signaling pathway, which plays a vital role in inflammation and immune response modulation.
Dysregulation of this pathway has been implicated in various diseases, including cancer, autoimmune disorders, and chronic inflammatory conditions. By studying the function of IL6R, researchers can gain insight into potential therapeutic targets for these conditions and develop novel treatment strategies. The IL6R Polyclonal Antibody (CAB1570) is an essential tool for investigating the role of IL6R in health and disease.
Product Name:
IL6R Rabbit Polyclonal Antibody
SKU:
CAB1570
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 20-365 of human IL6R (NP_000556.1).
Basolateral cell membrane, Secreted, Single-pass type I membrane protein.
Calculated MW:
52kDa
Observed MW:
70-100kDa
This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been identified in this gene. A pseudogene of this gene is found on chromosome 9.
Purification Method:
Affinity purification
Gene ID:
3570
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from THP-1 cells using IL6R Rabbit pAb(CAB1570) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25 μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
