IL6R Rabbit Polyclonal Antibody (CAB1570)
- SKU:
- CAB1570
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
Product Name: | IL6R Rabbit Polyclonal Antibody |
SKU: | CAB1570 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-365 of human IL6R (NP_000556.1). |
Sequence: | LAPR RCPA QEVA RGVL TSLP GDSV TLTC PGVE PEDN ATVH WVLR KPAA GSHP SRWA GMGR RLLL RSVQ LHDS GNYS CYRA GRPA GTVH LLVD VPPE EPQL SCFR KSPL SNVV CEWG PRST PSLT TKAV LLVR KFQN SPAE DFQE PCQY SQES QKFS CQLA VPEG DSSF YIVS MCVA SSVG SKFS KTQT FQGC GILQ PDPP ANIT VTAV ARNP RWLS VTWQ DPHS WNSS FYRL RFEL RYRA ERSK TFTT WMVK DLQH HCVI HDAW SGLR HVVQ LRAQ EEFG QGEW SEWS PEAM GTPW TESR SPPA ENEV STPM QALT TNKD DDNI LFRD SANA TSLP VQDS SSVP LP |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 |
Synonyms: | IL6Q; gp80; CD126; HIES5; IL-6R; IL6RA; IL6RQ; IL-1Ra; IL-6RA; IL6QTL; IL-6R-1; IL6R |
Positive Sample: | THP-1 |
Conjugate: | Unconjugated |
Cellular Localization: | Basolateral cell membrane, Secreted, Single-pass type I membrane protein. |
Calculated MW: | 52kDa |
Observed MW: | 70-100kDa |
This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been identified in this gene. A pseudogene of this gene is found on chromosome 9.
Purification Method: | Affinity purification |
Gene ID: | 3570 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |