The IL6 Polyclonal Antibody (CAB14687) is specifically designed for research involving interleukin-6 (IL-6), a multifunctional cytokine with roles in inflammation, immune response, and hematopoiesis. This antibody, raised in rabbits, is highly reactive with human samples and is validated for use in various applications including Western blot and immunohistochemistry.IL-6 is a key player in the inflammatory response and has been implicated in numerous diseases including cancer, autoimmune disorders, and cardiovascular diseases.
Studying the role of IL-6 in these conditions is crucial for developing targeted therapies and understanding disease progression.With the IL6 Polyclonal Antibody, researchers can accurately detect and analyze IL-6 expression in various cell types and tissues, making it an essential tool for studies in immunology, cancer research, and other fields. By utilizing this antibody, researchers can gain valuable insights into the function of IL-6 and its potential as a therapeutic target.
Product Name:
IL6 Rabbit Polyclonal Antibody
SKU:
CAB14687
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 30-212 of human IL6 (NP_000591.1).
This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. Elevated levels of the encoded protein have been found in virus infections, including COVID-19 (disease caused by SARS-CoV-2).
Purification Method:
Affinity purification
Gene ID:
3569
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from THP-1 cells, using IL6 Rabbit pAb (CAB14687) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.