The IL4R Polyclonal Antibody (CAB14648) is a vital tool for research involving the interleukin 4 receptor (IL4R), a key player in immune regulation and inflammation processes. This antibody, raised in rabbits, exhibits high reactivity with human samples and has been validated for use in a variety of applications, including Western blot and immunohistochemistry.The IL4R antibody specifically targets the IL4R protein, allowing for precise detection and analysis in various cell types. Its application in immunology and cancer research makes it an essential tool for studying the role of IL4R in immune responses, allergic reactions, and inflammation pathways.
IL4R plays a crucial role in regulating immune responses and has been implicated in various diseases, including cancer, autoimmune disorders, and chronic inflammatory conditions. Understanding the function of IL4R is essential for developing targeted therapies that modulate immune responses and inflammation, making the IL4R Polyclonal Antibody a valuable asset for researchers in the field.
Product Name:
IL4R Rabbit Polyclonal Antibody
SKU:
CAB14648
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 26-232 of human IL4R (NP_000409.1).
Cell membrane, Secreted, Single-pass type I membrane protein.
Calculated MW:
90kDa
Observed MW:
140kDa
This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
3566
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from Rat lung, using IL4R Rabbit pAb (CAB14648) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
