IL4R Rabbit Polyclonal Antibody (CAB14648)
- SKU:
- CAB14648
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
Product Name: | IL4R Rabbit Polyclonal Antibody |
SKU: | CAB14648 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 26-232 of human IL4R (NP_000409.1). |
Sequence: | MKVL QEPT CVSD YMSI STCE WKMN GPTN CSTE LRLL YQLV FLLS EAHT CIPE NNGG AGCV CHLL MDDV VSAD NYTL DLWA GQQL LWKG SFKP SEHV KPRA PGNL TVHT NVSD TLLL TWSN PYPP DNYL YNHL TYAV NIWS ENDP ADFR IYNV TYLE PSLR IAAS TLKS GISY RARV RAWA QCYN TTWS EWSP STKW HNSY REPF EQH |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:200 |
Synonyms: | CD124; IL4RA; IL-4RA; IL4R |
Positive Sample: | Mouse spleen,Rat lung |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Secreted, Single-pass type I membrane protein. |
Calculated MW: | 90kDa |
Observed MW: | 140kDa |
This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants.
Purification Method: | Affinity purification |
Gene ID: | 3566 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |