The IL4I1 Polyclonal Antibody (CAB8378) is a vital tool for researchers interested in studying IL4I1, an immune regulatory enzyme with implications in cancer and autoimmune diseases. This antibody, generated in rabbits, exhibits strong reactivity with human samples and is validated for use in Western blot applications. By specifically binding to the IL4I1 protein, researchers can accurately detect and analyze IL4I1 expression in various cell types, making it an ideal choice for investigations in immunology and cancer research.
IL4I1, also known as L-amino acid oxidase, plays a crucial role in immune regulation by modulating T cell responses and suppressing inflammation. Its involvement in immune tolerance and tumor evasion makes it a promising target for therapeutic strategies aimed at treating cancer and autoimmune disorders. The IL4I1 Polyclonal Antibody provides researchers with a valuable tool to better understand the function of IL4I1 and explore its potential as a therapeutic target in various disease contexts.
Product Name:
IL4I1 Rabbit Polyclonal Antibody
SKU:
CAB8378
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 22-220 of human IL4I1 (NP_690863.1).
This gene encodes a secreted L-amino acid oxidase protein which primarily catabolizes L-phenylalanine and, to a lesser extent, L-arginine. The expression of this gene is induced by the cytokine interleukin 4 in B cells. This gene is also expressed in macrophages and dendritic cells. This protein may play a role immune system escape as it is expressed in tumor-associated macrophages and suppresses T-cell responses. This protein also contains domains thought to be involved in the binding of flavin adenine dinucleotide (FAD) cofactor. Multiple transcript variants encoding different isoforms have been found for this gene. Some transcripts of this gene share a promoter and exons of the 5' UTR with the overlapping NUP62 gene.
Purification Method:
Affinity purification
Gene ID:
259307
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using IL4I1 Rabbit pAb (CAB8378) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
