The IL4 Monoclonal Antibody (CAB22284) is a valuable tool for researchers studying interleukin-4 (IL-4), a cytokine involved in regulating immune responses. This monoclonal antibody, generated in mice, is highly specific to IL-4 and is ideal for use in various research applications, including ELISA, Western blotting, and immunohistochemistry.IL-4 is known for its role in promoting T-cell differentiation and immunoglobulin class switching in B-cells, making it a key player in adaptive immune responses. Dysregulation of IL-4 signaling has been linked to autoimmune diseases, allergies, and inflammatory disorders, highlighting the importance of studying its functions and mechanisms of action.
By targeting IL-4 with this monoclonal antibody, researchers can gain valuable insights into the role of this cytokine in health and disease. Whether investigating immune response pathways or developing therapeutics for immune-related conditions, the IL4 Monoclonal Antibody (CAB22284) provides a reliable tool for accurate detection and analysis of IL-4 protein expression.
Product Name:
IL4 Monoclonal Antibody
SKU:
CAB22284
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 21-140 of mouse IL4 (NP_067258.1).
External side of plasma membrane, Extracellular space
Calculated MW:
16kDa
Observed MW:
19kDa
Enables cytokine activity. Involved in several processes, including innate immune response in mucosa; negative regulation of white fat cell proliferation; and regulation of gene expression. Acts upstream of or within several processes, including T-helper cell differentiation; positive regulation of macromolecule metabolic process; and regulation of leukocyte activation. Located in external side of plasma membrane and extracellular space. Is expressed in several structures, including brain; colon; hemolymphoid system; liver; and placenta. Used to study Sjogren's syndrome; atopic dermatitis; and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including asthma (multiple); autoimmune disease (multiple); hepatitis B; hepatitis C; and pancreatic cancer (multiple). Orthologous to human IL4 (interleukin 4).
Purification Method:
Affinity purification
Gene ID:
16189
Clone Number:
ARC56660
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates, using IL4 Rabbit mAb (CAB22284) at1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
