IL34 Antibody (PACO52458)
- SKU:
- PACO52458
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
IL34 Antibody (PACO52458)
The IL34 Polyclonal Antibody (PAC0528) is a valuable tool for researchers studying IL34, a cytokine that plays a crucial role in regulating the immune system and inflammation. This antibody, produced in rabbits, is highly specific to IL34 in human samples and has been validated for use in Western blot applications. By targeting the IL34 protein, researchers can accurately detect and analyze its presence in various cell types, making it ideal for studies in immunology, cancer research, and inflammation-related diseases.
IL34 is known for its role in promoting the differentiation and survival of certain immune cells, making it a key player in the regulation of immune responses. Its involvement in inflammatory processes makes it a promising target for research into conditions such as cancer, autoimmune disorders, and chronic inflammatory diseases. By understanding the functions of IL34, researchers can uncover new therapeutic avenues for manipulating immune responses in these pathological contexts.
| Antibody Name: | IL34 Antibody (PACO52458) |
| Antibody SKU: | PACO52458 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Interleukin-34 protein (191-240AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in: PC-3 whole cell lysate. All lanes: IL34 antibody at 4µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 28 kDa. Observed band size: 28 kDa. |
 | Immunohistochemistry of paraffin-embedded human small intestine tissue using PACO52458 at dilution of 1:100. |
| Background: | Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1. |
| Synonyms: | Interleukin-34 (IL-34), IL34, C16orf77 |
| UniProt Protein Function: | IL34: Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1. Belongs to the IL-34 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cytokine; Cell cycle regulation; Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 16q22.1 Cellular Component: extracellular region; extracellular space Molecular Function:macrophage colony stimulating factor receptor binding Biological Process: positive regulation of cell proliferation; positive regulation of macrophage differentiation; positive regulation of monocyte differentiation; positive regulation of protein amino acid phosphorylation |
| NCBI Summary: | Interleukin-34 is a cytokine that promotes the differentiation and viability of monocytes and macrophages through the colony-stimulating factor-1 receptor (CSF1R; MIM 164770) (Lin et al., 2008 [PubMed 18467591]).[supplied by OMIM, May 2008] |
| UniProt Code: | Q6ZMJ4 |
| NCBI GenInfo Identifier: | 74710540 |
| NCBI Gene ID: | 146433 |
| NCBI Accession: | Q6ZMJ4.1 |
| UniProt Secondary Accession: | Q6ZMJ4,Q8N6L2, B2RC28, B2Z4A8, B2ZC70, |
| UniProt Related Accession: | Q6ZMJ4 |
| Molecular Weight: | 27,354 Da |
| NCBI Full Name: | Interleukin-34 |
| NCBI Synonym Full Names: | interleukin 34 |
| NCBI Official Symbol: | IL34Â Â |
| NCBI Official Synonym Symbols: | IL-34; C16orf77Â Â |
| NCBI Protein Information: | interleukin-34 |
| UniProt Protein Name: | Interleukin-34 |
| Protein Family: | Interleukin |
| UniProt Gene Name: | IL34Â Â |
| UniProt Entry Name: | IL34_HUMAN |
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