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IL33 Monoclonal Antibody [P4E9AT] (CPAB0066)

SKU:
CPAB0066
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG2b
Clone:
P4E9AT
Applications:
WB
ELISA
€149
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Description

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IL33 Monoclonal Antibody [P4E9AT] (CPAB0066)

The IL33 Polyclonal Antibody (CPAB0066) is a vital tool for researchers studying IL33, a cytokine involved in immune response and inflammation regulation. This antibody, generated in rabbits, exhibits high reactivity with human samples and is validated for use in Western blotting applications. Its specificity towards the IL33 protein allows for accurate detection and analysis in various cell types, making it an excellent choice for studies in immunology and inflammatory diseases.IL33, known as a proinflammatory cytokine, plays a crucial role in the activation of immune cells and the regulation of inflammatory responses.

Its involvement in various inflammatory conditions and diseases, including asthma, allergies, and autoimmune disorders, makes it a compelling target for research in understanding the mechanisms underlying these conditions. By studying the function of IL33, researchers can potentially uncover new insights that could lead to the development of novel therapeutic approaches for treating inflammatory diseases.

Product Name:IL33 Antibody
Product Sku:CPAB0066
Size:5μg
Host Species:Mouse
Immunogen:Anti-human IL33 mAb, is derived from hybridization of mouse F myeloma cells with spleen cells from BALB/c mice immunized with Recombinant human IL33 amino acids 112-27 purified from Ecoli.
Clone:P4E9AT.
Reactivity:Human
Applications:Western Blot, ELISA
Purification Method:IL33 antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
Isotype:IgG2b
Background:Interleukin 33 (IL-33) is a 32kDa proinflammatory cytokine that may also regulate gene transcription in producer cells. IL-33 is structurally related to IL-1, which induces helper T cells to produce type 2 cytokines and acts through the receptor IL1RL-1 (IL1 receptor-like-1), which is known also as ST2. Binding of IL-33 to this receptor activates NF-kappa-B and MAP kinases and induces in vitro Th2 cells to produce cytokines. In vivo, IL-33 induces expression of IL-4, IL-5, IL-13 and leads to severe pathological changes in mucosal organs and in vitro, it can be divided to N-terminal fragment of 12kDa and C-terminal fragment of 18kDa by cleavage of caspase-1.
Synonyms:Interleukin 33, DVS27, NF-HEV, NKHEV, C9orf26, Interleukin-1 family member 11, IL- 1F11, Nuclear factor from high endothelial venules, NFEHEV, DKFZp586H0523, RP11-575C20.2, IL-33.
Storage Buffer:For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.

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