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IL32 Monoclonal Antibody [PAT2F9AT] (CPAB0010)

SKU:
CPAB0010
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG1
Clone:
PAT2F9AT
Applications:
WB
ELISA
€149
Frequently bought together:

Description

system_update_alt Datasheet

IL32 Monoclonal Antibody [PAT2F9AT] (CPAB0010)

The IL32 Polyclonal Antibody (CPAB0010) is a valuable tool for researchers studying Interleukin-32 (IL-32), a pro-inflammatory cytokine involved in various immune responses and inflammatory processes. This antibody, generated in rabbits, exhibits high specificity and sensitivity towards IL-32 in human samples, making it ideal for applications such as Western blotting and immunohistochemistry.IL-32 is known to play a crucial role in the pathogenesis of inflammatory conditions, autoimmune diseases, and certain types of cancer.

By targeting IL-32, researchers can gain insights into the mechanisms underlying these diseases and potentially identify new therapeutic targets. The IL32 Polyclonal Antibody is a reliable reagent for studying the expression and function of IL-32 in different cell types, providing valuable information for immunology and cancer research efforts.

Product Name:IL32 Antibody
Product Sku:CPAB0010
Size:5μg
Host Species:Mouse
Immunogen:Anti-human IL32 mAb, is derived from hybridization of mouse F myeloma cells with spleen cells from BALB/c mice immunized with recombinant human IL32 amino acids 1-331 purified from Ecoli.
Clone:PAT2F9AT.
Reactivity:Human
Applications:Western Blot, ELISA
Purification Method:IL32 antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
Isotype:IgG1
Background:IL-32 is part of the cytokine family and contains a tyrosine sulfation site, 3 potential N-myristoylation sites, multiple putative phosphorylation sites, and an RGD cell-attachment sequence. IL-32 expression is elevated after the activation of T-cells by mitogens or the activation of NK cells by IL-2. IL-32 induces the production of TNF-a from macrophage cells. IL-32 pro-inflammatory pathway is activated in response to influenza A virus infection. Dysregulation of IL-32 in myelodysplastic syndrome and chronic myelomonocytic leukemia modulates apoptosis and impairs NK function. Induction of TNF, IL-1beta, and IL-6 by IL-32 is intervened by p38-MAPK. IL-32 induced monocyte-to-macrophage differentiation is mediated through nonapoptotic, caspase-3-dependent mechanisms. IL32 plays an important role in the pathogenesis of rheumatoid arthritis. IL-32 is involved in activation-induced cell death in T cells, through its intracellular actions. IL-32 is a cell-associated proinflammatory cytokine.
Synonyms:NK4, TAIF, TAIFa, TAIFb, TAIFc, TAIFd, IL-32beta, IL-32alpha, IL-32delta, IL-32gamma, Interleukin-32, IL-32, Natural killer cells protein 4, Tumor necrosis factor alpha-inducing factor, IL-32a, IL32a, IL32, Interleukin-32 alpha.
Storage Buffer:For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.

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