The IL31RA Polyclonal Antibody (CAB6141) is a valuable tool for researchers studying IL31RA, a receptor for the cytokine IL-31 which plays a key role in immune regulation and inflammation. This antibody, raised in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to IL31RA, this antibody allows for the detection and analysis of this important receptor in various cell types.IL31RA is involved in the regulation of inflammatory responses and has been implicated in conditions such as atopic dermatitis, allergic asthma, and other inflammatory skin disorders.
Understanding the role of IL31RA in these diseases can provide insights into potential therapeutic targets for treating inflammatory and immune-mediated conditions.Overall, the IL31RA Polyclonal Antibody is an essential tool for researchers interested in studying the role of IL31RA in immune response modulation and inflammatory diseases. Its high reactivity and specificity make it a reliable choice for immunology and inflammation research studies.
Product Name:
IL31RA Rabbit Polyclonal Antibody
SKU:
CAB6141
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 20-321 of human IL31RA (NP_001284501.1).
Cell membrane, Single-pass type I membrane protein.
Calculated MW:
83kDa
Observed MW:
41kDa/70kDa
The protein encoded by this gene belongs to the type I cytokine receptor family. This receptor, with homology to gp130, is expressed on monocytes, and is involved in IL-31 signaling via activation of STAT-3 and STAT-5. It functions either as a monomer, or as part of a receptor complex with oncostatin M receptor (OSMR). Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
Purification Method:
Affinity purification
Gene ID:
133396
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from U-87MG cells, using IL31RA Rabbit pAb (CAB6141) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
