The IL2RG Polyclonal Antibody (CAB1829) is a valuable tool for research involving the Interleukin-2 receptor subunit gamma (IL2RG), a crucial component of the IL-2 receptor complex. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By specifically binding to the IL2RG protein, researchers can easily detect and analyze its expression in various cell types, making it an ideal choice for studies in immunology and cancer research.
IL2RG is a key player in immune response regulation, as it is essential for signaling pathways that promote T-cell proliferation and survival. Dysregulation of IL2RG expression is associated with various immune disorders and autoimmune diseases, making it an important target for therapeutic interventions. By studying the role of IL2RG in immune responses, researchers can gain valuable insights into potential treatment strategies for conditions such as cancer, autoimmune disorders, and inflammatory diseases.
Product Name:
IL2RG Rabbit Polyclonal Antibody
SKU:
CAB1829
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 290-369 of human CD132/IL-2 R gamma (NP_000197.1).
P64; CIDX; IMD4; CD132; SCIDX; IL-2RG; SCIDX1; CD132/IL-2 R gamma
Positive Sample:
HepG2,Jurkat,Raji,RAW264.7,THP-1
Conjugate:
Unconjugated
Cellular Localization:
Membrane, Single-pass type I membrane protein.
Calculated MW:
42kDa
Observed MW:
70kDa
The protein encoded by this gene is an important signaling component of many interleukin receptors, including those of interleukin -2, -4, -7 and -21, and is thus referred to as the common gamma chain. Mutations in this gene cause X-linked severe combined immunodeficiency (XSCID), as well as X-linked combined immunodeficiency (XCID), a less severe immunodeficiency disorder.
Purification Method:
Affinity purification
Gene ID:
3561
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using CD132/IL-2 R gamma antibody (CAB1829) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
