The IL2RB Polyclonal Antibody (CAB6207) is specially developed for research involving IL2RB, a cell surface receptor important for immune system regulation. This antibody, raised in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot experiments. By binding to the IL2RB protein, this antibody allows for the detection and analysis of IL2RB in various cell types, making it a valuable tool for studies in immunology and cancer research.IL2RB, also known as interleukin-2 receptor subunit beta, plays a crucial role in immune function by participating in the signaling pathway of interleukin-2, a key cytokine involved in T cell activation and proliferation.
Dysregulation of IL2RB signaling has been associated with various autoimmune diseases and cancer, highlighting its importance as a potential therapeutic target. Research into the function of IL2RB is essential for developing novel treatments that modulate immune responses in diseases such as cancer and autoimmune disorders.
Product Name:
IL2RB Rabbit Polyclonal Antibody
SKU:
CAB6207
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 316-431 of human IL2RB (NP_000869.1).
The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. The protein encoded by this gene represents the beta subunit and is a type I membrane protein. The use of alternative promoters results in multiple transcript variants encoding the same protein. The protein is primarily expressed in the hematopoietic system. The use by some variants of an alternate promoter in an upstream long terminal repeat (LTR) results in placenta-specific expression.
Purification Method:
Affinity purification
Gene ID:
3560
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using IL2RB antibody (CAB6207) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
