The IL2RA Polyclonal Antibody (CAB2984) is a valuable tool for research involving the interleukin-2 receptor alpha (IL2RA), a protein involved in T cell activation and immune response regulation. This antibody, raised in rabbits, is highly specific for human samples and has been validated for use in Western blot applications.IL2RA plays a crucial role in the immune system, particularly in the activation and proliferation of T cells. Dysregulation of IL2RA has been implicated in various autoimmune diseases and inflammatory conditions, making it a key target for research in immunology and cancer biology.
By binding to IL2RA, this antibody enables researchers to detect and analyze the expression of this important protein in various cell types, providing valuable insights into its function and potential as a therapeutic target. Studies using this antibody can contribute to our understanding of immune regulation and the development of novel treatments for immune-related disorders.
Product Name:
IL2RA Rabbit Polyclonal Antibody
SKU:
CAB2984
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 101-200 of human CD25 (NP_000408.1).
The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency. Patients with severe Coronavirus Disease 2019 (COVID-19), the disease caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), have significantly elevated levels of IL2R in their plasma. Similarly, serum IL-2R levels are found to be elevated in patients with different types of carcinomas. Certain IL2RA and IL2RB gene polymorphisms have been associated with lung cancer risk.
Purification Method:
Affinity purification
Gene ID:
3559
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using CD25 Rabbit pAb (CAB2984) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3s.
