IL2RA Rabbit Polyclonal Antibody (CAB2984)
- SKU:
- CAB2984
- Product Type:
- Antibody
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Immunology
Description
Product Name: | IL2RA Rabbit Polyclonal Antibody |
SKU: | CAB2984 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 101-200 of human CD25 (NP_000408.1). |
Sequence: | QKER KTTE MQSP MQPV DQAS LPGH CREP PPWE NEAT ERIY HFVV GQMV YYQC VQGY RALH RGPA ESVC KMTH GKTR WTQP QLIC TGEM ETSQ FPGE EKPQ |
Tested Applications: | WB IHC-P IF/ICC FC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 FC,1:50 - 1:200 |
Synonyms: | p55; CD25; IL2R; IMD41; TCGFR; IDDM10 |
Positive Sample: | Rat spleen,Rat lung |
Conjugate: | Unconjugated |
Cellular Localization: | Membrane, Single-pass type I membrane protein. |
Calculated MW: | 31kDa |
Observed MW: | 60kDa |
The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency. Patients with severe Coronavirus Disease 2019 (COVID-19), the disease caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), have significantly elevated levels of IL2R in their plasma. Similarly, serum IL-2R levels are found to be elevated in patients with different types of carcinomas. Certain IL2RA and IL2RB gene polymorphisms have been associated with lung cancer risk.
Purification Method: | Affinity purification |
Gene ID: | 3559 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |