The IL27 Polyclonal Antibody (CAB5498) is a valuable tool for researchers studying the role of interleukin 27 (IL27) in immune regulation and inflammation. IL27 is a cytokine that plays a key role in modulating the immune response, with both pro- and anti-inflammatory effects depending on the context.This antibody is raised in rabbits and is highly specific for IL27, making it suitable for use in Western blot applications with human samples. By binding to the IL27 protein, this antibody enables researchers to detect and analyze IL27 expression in various cell types, providing valuable insights into its function in immunology and disease.IL27 is known to have diverse effects on immune cells, including promoting the differentiation of regulatory T cells and suppressing the production of pro-inflammatory cytokines.
Research on IL27 has implications for understanding autoimmune diseases, infectious diseases, and cancer, making this antibody a versatile tool for investigating the role of IL27 in various pathological conditions.Overall, the IL27 Polyclonal Antibody (CAB5498) is a reliable reagent for researchers interested in studying the complex role of IL27 in immune regulation and disease pathogenesis. Its specificity and sensitivity make it a valuable asset for experiments aimed at unraveling the intricate mechanisms underlying immune responses and inflammatory processes.
Product Name:
IL27 Rabbit Polyclonal Antibody
SKU:
CAB5498
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 29-243 of human IL27 (NP_663634.2).
The protein encoded by this gene is one of the subunits of a heterodimeric cytokine complex. This protein is related to interleukin 12A (IL12A). It interacts with Epstein-Barr virus induced gene 3 (EBI3), a protein similar to interleukin 12B (IL12B), and forms a complex that has been shown to drive rapid expansion of naive but not memory CD4(+) T cells. The complex is also found to synergize strongly with interleukin 12 to trigger interferon gamma (IFNG) production of naive CD4(+) T cells. The biological effects of this cytokine are mediated by the class I cytokine receptor (WSX1/TCRR).
Purification Method:
Affinity purification
Gene ID:
246778
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using IL27 Rabbit pAb (CAB5498) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
