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IL24 Rabbit Polyclonal Antibody (CAB1879)

SKU:
CAB1879
Product Type:
Antibody
Reactivity:
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Death
  • Cell Death Antibodies 1 Anti-IL-24 Antibody CAB1879
  • Cell Death Antibodies 1 Anti-IL-24 Antibody CAB1879
€139 - €419
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Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:IL24 Rabbit Polyclonal Antibody
SKU:CAB1879
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Mouse,Rat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 52-140 of human IL24 (NP_001172085.1).
Sequence:GQEF HFGP CQVK GVVP QKLW EAFW AVKD TMQA QDNI TSAR LLQQ EVLQ NVSD AESC YLVH TLLE FYLK TVFK NYHN RTVE VRTL KSFS T
Tested Applications:WB IHC-P ELISA
Recommended Dilution:WB,1:500 - 1:2000 IHC-P,1:50 - 1:200
Synonyms:C49A; FISP; MDA7; MOB5; ST16; IL10B; IL24
Positive Sample:Mouse lung,Rat lung
Conjugate:Unconjugated
Cellular Localization:Secreted.
Calculated MW:24kDa
Observed MW:26kDa

This gene encodes a member of the IL10 family of cytokines. It was identified as a gene induced during terminal differentiation in melanoma cells. The protein encoded by this gene can induce apoptosis selectively in various cancer cells. Overexpression of this gene leads to elevated expression of several GADD family genes, which correlates with the induction of apoptosis. The phosphorylation of mitogen-activated protein kinase 14 (MAPK7/P38), and heat shock 27kDa protein 1 (HSPB2/HSP27) are found to be induced by this gene in melanoma cells, but not in normal immortal melanocytes. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

Purification Method:Affinity purification
Gene ID:11009
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Product ImageWestern blot analysis of various lysates using IL24 Rabbit pAb (CAB1879) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.

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