The IL23A Polyclonal Antibody (PAC052074) is a valuable tool for researchers studying IL23A, a key cytokine involved in immune responses and inflammation. This antibody, produced in rabbits, exhibits high reactivity with human samples and is suitable for use in Western blotting applications. By binding specifically to IL23A, this antibody enables precise detection and analysis of the protein in various cell types, making it ideal for investigations in immunology and inflammatory diseases.IL23A, also known as interleukin-23 subunit alpha, plays a crucial role in promoting inflammation and regulating immune responses. Dysregulation of IL23A has been implicated in various autoimmune disorders, chronic inflammatory conditions, and cancer.
Therefore, studying the function of IL23A is essential for developing targeted therapies that modulate the immune system and alleviate disease progression.This IL23A Polyclonal Antibody is a valuable tool for researchers looking to deepen their understanding of IL23A's role in immune regulation and disease pathology. With its high specificity and sensitivity, this antibody is an essential component for any research project investigating the functions and implications of IL23A in health and disease.
Immunohistochemistry of paraffin-embedded human small intestine tissue using PACO52074 at dilution of 1:100.
Immunofluorescent analysis of HepG2 cells using PACO52074 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.
IL23A: Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak- Stat signaling cascade, stimulates memory rather than naive T- cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis. Belongs to the IL-6 superfamily.Protein type: Secreted, signal peptide; Cytokine; SecretedChromosomal Location of Human Ortholog: 12q13.3Molecular Function: cytokine activity; interleukin-23 receptor binding; protein bindingBiological Process: defense response to Gram-negative bacterium; defense response to virus; inflammatory response; innate immune response; negative regulation of interleukin-10 production; positive regulation of activated T cell proliferation; positive regulation of defense response to virus by host; positive regulation of granulocyte macrophage colony-stimulating factor production; positive regulation of inflammatory response; positive regulation of interferon-gamma production; positive regulation of interleukin-10 production; positive regulation of interleukin-12 production; positive regulation of interleukin-17 production; positive regulation of memory T cell differentiation; positive regulation of natural killer cell activation; positive regulation of natural killer cell proliferation; positive regulation of NF-kappaB import into nucleus; positive regulation of NK T cell activation; positive regulation of NK T cell proliferation; positive regulation of osteoclast differentiation; positive regulation of T cell mediated cytotoxicity; positive regulation of T cell proliferation; positive regulation of T-helper 1 type immune response; positive regulation of tissue remodeling; positive regulation of transcription from RNA polymerase II promoter; positive regulation of tumor necrosis factor production; positive regulation of tyrosine phosphorylation of Stat3 protein; positive regulation of tyrosine phosphorylation of Stat4 protein; positive regulation of tyrosine phosphorylation of Stat5 protein; regulation of tyrosine phosphorylation of Stat1 protein; T cell proliferation; tissue remodeling
UniProt Protein Details:
NCBI Summary:
This gene encodes a subunit of the heterodimeric cytokine interleukin 23 (IL23). IL23 is composed of this protein and the p40 subunit of interleukin 12 (IL12B). The receptor of IL23 is formed by the beta 1 subunit of IL12 (IL12RB1) and an IL23 specific subunit, IL23R. Both IL23 and IL12 can activate the transcription activator STAT4, and stimulate the production of interferon-gamma (IFNG). In contrast to IL12, which acts mainly on naive CD4(+) T cells, IL23 preferentially acts on memory CD4(+) T cells. [provided by RefSeq, Jul 2008]
