IL21R Rabbit Polyclonal Antibody (CAB7468)
- SKU:
- CAB7468
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | IL21R Rabbit Polyclonal Antibody |
SKU: | CAB7468 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-240 of human IL21R (NP_851565.4). |
Sequence: | GVSM PRGW AAPL LLLL LQGG WGCP DLVC YTDY LQTV ICIL EMWN LHPS TLTL TWQD QYEE LKDE ATSC SLHR SAHN ATHA TYTC HMDV FHFM ADDI FSVN ITDQ SGNY SQEC GSFL LAES IKPA PPFN VTVT FSGQ YNIS WRSD YEDP AFYM LKGK LQYE LQYR NRGD PWAV SPRR KLIS VDSR SVSL LPLE FRKD SSYE LQVR AGPM PGSS YQGT WSEW S |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | NILR; CD360; IMD56; IL21R |
Positive Sample: | U-87MG,Mouse spleen,Mouse thymus |
Conjugate: | Unconjugated |
Cellular Localization: | Membrane, Single-pass type I membrane protein. |
Calculated MW: | 59kDa |
Observed MW: | 70kDa |
The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2, 4, 7, 9, and 15. This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants have been described.
Purification Method: | Affinity purification |
Gene ID: | 50615 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |