The IL2 Polyclonal Antibody (CAB16317) is a valuable tool for researchers studying interleukin-2 (IL-2), a cytokine involved in the regulation of immune responses. Raised in rabbits, this antibody demonstrates high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the IL2 protein, this antibody allows for the detection and analysis of IL-2 in various cell types, making it an essential component for studies in immunology and cancer research.IL-2 is a critical factor in the proliferation and differentiation of T cells, key players in the immune response.
Dysregulation of IL-2 is associated with various diseases, including autoimmune disorders and cancer. Therefore, understanding the role of IL-2 in immune function is essential for developing targeted therapies for these conditions.Overall, the IL2 Polyclonal Antibody (CAB16317) is a valuable tool for researchers looking to further their understanding of IL-2 and its implications in immune system regulation and disease development.
Product Name:
IL2 Rabbit Polyclonal Antibody
SKU:
CAB16317
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 21-153 of IL2 (NP_000577.2).
This gene is a member of the interleukin 2 (IL2) cytokine subfamily which includes IL4, IL7, IL9, IL15, IL21, erythropoietin, and thrombopoietin. The protein encoded by this gene is a secreted cytokine produced by activated CD4+ and CD8+ T lymphocytes, that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine (IL2R) is a heterotrimeric protein complex whose gamma chain is also shared by IL4 and IL7. The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli.
Purification Method:
Affinity purification
Gene ID:
3558
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from Recombinat Human IL2 Protein, using IL2 Rabbit pAb (CAB16317) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
