The IL1RN Polyclonal Antibody (CAB16385) is a key tool for researchers studying IL1RN, a crucial regulator of the immune system's inflammatory responses. This antibody, produced in rabbits, exhibits high specificity for human samples and is validated for use in Western blot applications. By targeting the IL1RN protein, researchers can accurately detect and analyze its presence in a variety of cell types, making it an invaluable resource for studies in immunology and disease research.IL1RN, also known as interleukin 1 receptor antagonist, functions as a natural anti-inflammatory protein that blocks the effects of pro-inflammatory cytokines like IL-1.
Its role in modulating immune responses highlights its potential as a therapeutic target for conditions characterized by excessive inflammation, such as autoimmune diseases and chronic inflammatory disorders. Investigating IL1RN's mechanisms of action is essential for developing novel treatments that regulate immune responses and promote immune system balance in pathological conditions.
Product Name:
IL1RA Rabbit Polyclonal Antibody
SKU:
CAB16385
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-159 of human IL1RA (NP_000568.1).
DIRA; IRAP; IL1F3; IL1RA; MVCD4; IL-1RN; IL-1ra; IL-1ra3; ICIL-1RA
Positive Sample:
Mouse pancreas
Conjugate:
Unconjugated
Cellular Localization:
Cytoplasm, Secreted.
Calculated MW:
20kDa
Observed MW:
20kDa
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses, particularly in the acute phase of infection and inflammation. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Several alternatively spliced transcript variants encoding distinct isoforms have been reported.
Purification Method:
Affinity purification
Gene ID:
3557
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from mouse pancreas, using IL1RA Rabbit pAb (CAB16385) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
