The IL1R2 Polyclonal Antibody (CAB1899) is specifically designed for research involving IL1R2, a cell surface receptor involved in inflammatory responses. The antibody, raised in rabbits, is highly reactive with human samples and is validated for use in various applications such as Western blot and immunohistochemistry. It binds to the IL1R2 receptor, enabling detection and analysis in different cell types, making it an ideal tool for studies in immunology and inflammatory diseases.IL1R2, also known as IL-1 receptor type 2, is a key regulator in the interleukin-1 signaling pathway, playing a critical role in modulating the inflammatory response.
Dysregulation of IL1R2 has been implicated in various inflammatory conditions, making it a promising target for drug development and therapeutic interventions. Understanding the function of IL1R2 is essential for advancing research in areas such as autoimmune disorders, infectious diseases, and chronic inflammatory conditions.Overall, the IL1R2 Polyclonal Antibody (CAB1899) offers researchers a reliable tool for studying the role of IL1R2 in inflammation, offering insights that could contribute to the development of novel treatments for inflammatory diseases.
Product Name:
IL1R2 Rabbit Polyclonal Antibody
SKU:
CAB1899
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 20-320 of human IL1R2 (NP_775465.1).
Cell membrane, Secreted, Single-pass type I membrane protein.
Calculated MW:
45kDa
Observed MW:
45kDa/60-70kDa/45kDa
The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. Alternative splicing results in multiple transcript variants and protein isoforms. Alternative splicing produces both membrane-bound and soluble proteins. A soluble protein is also produced by proteolytic cleavage.
Purification Method:
Affinity purification
Gene ID:
7850
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from A-431 cells, using IL1R2 Rabbit pAb (CAB1899) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
