The IL18RAP Polyclonal Antibody (PAC015187) is a valuable tool for researchers studying the IL18RAP protein, which plays a key role in the immune system. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to IL18RAP, this antibody allows for accurate detection and analysis of the protein in a variety of cell types, making it an essential tool for studies in immunology and cancer research.IL18RAP is a critical component in the regulation of immune responses, particularly in the activation of T-cells and the production of inflammatory cytokines. Its involvement in these processes makes IL18RAP a target of interest in research on diseases such as cancer, autoimmune disorders, and inflammatory conditions.
Understanding the function of IL18RAP is crucial for developing targeted therapies that utilize or modulate the immune system in these disease contexts.In conclusion, the IL18RAP Polyclonal Antibody (PAC015187) is a reliable tool for researchers looking to study the IL18RAP protein and its role in immune regulation. Its high specificity and validated performance make it an essential component in research aimed at understanding and treating a variety of diseases related to immune dysfunction.
Antibody Name:
IL18RAP Antibody (PACO15187)
Antibody SKU:
PACO15187
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:5000, WB:1:500-1:2000
Species Reactivity:
Human, Mouse
Immunogen:
Fusion protein of human IL18RAP
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-3: RAW264.7 cells, human liver cancer tissue, SP20 cell, Primary antibody: PACO15187(IL18RAP Antibody) at dilution 1/650, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute.
Background:
Interleukin 18 receptor accessory protein, also known as IL18RAP and CDw218b (cluster of differentiationw218b), is a human gene. The protein encoded by this gene is an accessory subunit of the heterodimeric receptor for IL18. This protein enhances the IL18 binding activity of IL18R1 (IL1RRP), a ligand binding subunit of IL18 receptor. The coexpression of IL18R1 and this protein is required for the activation of NF- κ B and MAPK8 (JNK) in response to IL18.
Synonyms:
Interleukin 18 receptor accessory protein
UniProt Protein Function:
IL18RAP: Required for the high affinity binding of interleukin 18 (IL-18) to its receptor complex. Together with IL18R1 mediates IL-18-dependent activation of NF-kappa-B and JNK. Belongs to the interleukin-1 receptor family.Protein type: Cell surface; Membrane protein, integralChromosomal Location of Human Ortholog: 2q12Cellular Component: integral to membraneMolecular Function: receptor activityBiological Process: cell surface receptor linked signal transduction; immune response; inflammatory response
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is an accessory subunit of the heterodimeric receptor for interleukin 18 (IL18), a proinflammatory cytokine involved in inducing cell-mediated immunity. This protein enhances the IL18-binding activity of the IL18 receptor and plays a role in signaling by IL18. Mutations in this gene are associated with Crohn's disease and inflammatory bowel disease, and susceptibility to celiac disease and leprosy. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2014]
