| UniProt Protein Function: | IL17RC: a single-pass type I membrane protein that shares similarity with the interleukin-17 receptor (IL-17RA). Unlike IL-17RA, which is predominantly expressed in hemopoietic cells, and binds with high affinity to only IL-17A, this protein is expressed in nonhemopoietic tissues, and binds both IL-17A and IL-17F with similar affinities. The proinflammatory cytokines, IL-17A and IL-17F, have been implicated in the progression of inflammatory and autoimmune diseases. Multiple alternatively spliced transcript variants encoding different isoforms have been detected for this gene, and it has been proposed that soluble, secreted proteins lacking transmembrane and intracellular domains may function as extracellular antagonists to cytokine signaling. [provided by RefSeq, Feb 2011]Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 3p25.3|3p25.3-p24.1Cellular Component: integral to plasma membraneMolecular Function: interleukin-17 receptor activityBiological Process: cytokine and chemokine mediated signaling pathwayDisease: Candidiasis, Familial, 9 |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a single-pass type I membrane protein that shares similarity with the interleukin-17 receptor (IL-17RA). Unlike IL-17RA, which is predominantly expressed in hemopoietic cells, and binds with high affinity to only IL-17A, this protein is expressed in nonhemopoietic tissues, and binds both IL-17A and IL-17F with similar affinities. The proinflammatory cytokines, IL-17A and IL-17F, have been implicated in the progression of inflammatory and autoimmune diseases. Multiple alternatively spliced transcript variants encoding different isoforms have been detected for this gene, and it has been proposed that soluble, secreted proteins lacking transmembrane and intracellular domains may function as extracellular antagonists to cytokine signaling. [provided by RefSeq, Feb 2011] |
| UniProt Code: | Q8NAC3 |
| NCBI GenInfo Identifier: | 229462881 |
| NCBI Gene ID: | 84818 |
| NCBI Accession: | Q8NAC3.2 |
| UniProt Secondary Accession: | Q8NAC3,Q6UVY3, Q6UWD4, Q8NFS1, Q9BR97, E9PHG1, E9PHJ6 |
| UniProt Related Accession: | Q8NAC3 |
| Molecular Weight: | |
| NCBI Full Name: | Interleukin-17 receptor C |
| NCBI Synonym Full Names: | interleukin 17 receptor C |
| NCBI Official Symbol: | IL17RCÂ Â |
| NCBI Official Synonym Symbols: | IL17RL; IL17-RLÂ Â |
| NCBI Protein Information: | interleukin-17 receptor C; IL-17 receptor C; IL-17RL; IL17F receptor; IL17Rhom; interleukin-17 receptor homolog; interleukin-17 receptor-like protein; zcytoR14 |
| UniProt Protein Name: | Interleukin-17 receptor C |
| UniProt Synonym Protein Names: | Interleukin-17 receptor homolog; IL17Rhom; Interleukin-17 receptor-like protein; IL-17RL; ZcytoR14 |
| Protein Family: | Interleukin-17 receptor |
| UniProt Gene Name: | IL17RCÂ Â |
| UniProt Entry Name: | I17RC_HUMAN |
