IL17RC Antibody (PACO13976)
- SKU:
- PACO13976
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
IL17RC Antibody (PACO13976)
The IL17RC Polyclonal Antibody (PAC013976) is a valuable tool for researchers studying IL17RC, a cell surface receptor involved in the regulation of immune responses. This antibody was raised in rabbits and is highly reactive with human samples, making it ideal for use in experiments such as Western blotting. By binding to the IL17RC protein, this antibody allows for the detection and analysis of IL17RC expression in different cell types.IL17RC, also known as IL-17 receptor C, plays a crucial role in immune signaling pathways and has been implicated in various inflammatory conditions and autoimmune diseases.
By studying IL17RC activity, researchers can gain insights into the mechanisms underlying these diseases and potentially develop new therapeutic strategies. The IL17RC Polyclonal Antibody is a valuable tool for investigating the function of IL17RC and its potential role in disease pathology.
| Antibody Name: | IL17RC Antibody (PACO13976) |
| Antibody SKU: | PACO13976 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:1000-1:10000, IHC:1:25-1:100 |
| Species Reactivity: | Human |
| Immunogen: | Fusion protein of human IL17RC |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using PACO13976(IL17RC Antibody) at dilution 1/20. (Original magnification: x200). |
 | The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO13976(IL17RC Antibody) at dilution 1/20. (Original magnification: x200). |
| Background: | This gene encodes a single-pass type I membrane protein that shares similarity with the interleukin-17 receptor (IL-17RA). Unlike IL-17RA, which is predominantly expressed in hemopoietic cells, and binds with high affinity to only IL-17A, this protein is expressed in nonhemopoietic tissues, and binds both IL-17A and IL-17F with similar affinities. The proinflammatory cytokines, IL-17A and IL-17F, have been implicated in the progression of inflammatory and autoimmune diseases. Multiple alternatively spliced transcript variants encoding different isoforms have been detected for this gene, and it has been proposed that soluble, secreted proteins lacking transmembrane and intracellular domains may function as extracellular antagonists to cytokine signaling. |
| Synonyms: | Interleukin-17 receptor C |
| UniProt Protein Function: | IL17RC: a single-pass type I membrane protein that shares similarity with the interleukin-17 receptor (IL-17RA). Unlike IL-17RA, which is predominantly expressed in hemopoietic cells, and binds with high affinity to only IL-17A, this protein is expressed in nonhemopoietic tissues, and binds both IL-17A and IL-17F with similar affinities. The proinflammatory cytokines, IL-17A and IL-17F, have been implicated in the progression of inflammatory and autoimmune diseases. Multiple alternatively spliced transcript variants encoding different isoforms have been detected for this gene, and it has been proposed that soluble, secreted proteins lacking transmembrane and intracellular domains may function as extracellular antagonists to cytokine signaling. [provided by RefSeq, Feb 2011]Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 3p25.3|3p25.3-p24.1Cellular Component: integral to plasma membraneMolecular Function: interleukin-17 receptor activityBiological Process: cytokine and chemokine mediated signaling pathwayDisease: Candidiasis, Familial, 9 |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a single-pass type I membrane protein that shares similarity with the interleukin-17 receptor (IL-17RA). Unlike IL-17RA, which is predominantly expressed in hemopoietic cells, and binds with high affinity to only IL-17A, this protein is expressed in nonhemopoietic tissues, and binds both IL-17A and IL-17F with similar affinities. The proinflammatory cytokines, IL-17A and IL-17F, have been implicated in the progression of inflammatory and autoimmune diseases. Multiple alternatively spliced transcript variants encoding different isoforms have been detected for this gene, and it has been proposed that soluble, secreted proteins lacking transmembrane and intracellular domains may function as extracellular antagonists to cytokine signaling. [provided by RefSeq, Feb 2011] |
| UniProt Code: | Q8NAC3 |
| NCBI GenInfo Identifier: | 229462881 |
| NCBI Gene ID: | 84818 |
| NCBI Accession: | Q8NAC3.2 |
| UniProt Secondary Accession: | Q8NAC3,Q6UVY3, Q6UWD4, Q8NFS1, Q9BR97, E9PHG1, E9PHJ6 |
| UniProt Related Accession: | Q8NAC3 |
| Molecular Weight: | |
| NCBI Full Name: | Interleukin-17 receptor C |
| NCBI Synonym Full Names: | interleukin 17 receptor C |
| NCBI Official Symbol: | IL17RCÂ Â |
| NCBI Official Synonym Symbols: | IL17RL; IL17-RLÂ Â |
| NCBI Protein Information: | interleukin-17 receptor C; IL-17 receptor C; IL-17RL; IL17F receptor; IL17Rhom; interleukin-17 receptor homolog; interleukin-17 receptor-like protein; zcytoR14 |
| UniProt Protein Name: | Interleukin-17 receptor C |
| UniProt Synonym Protein Names: | Interleukin-17 receptor homolog; IL17Rhom; Interleukin-17 receptor-like protein; IL-17RL; ZcytoR14 |
| Protein Family: | Interleukin-17 receptor |
| UniProt Gene Name: | IL17RCÂ Â |
| UniProt Entry Name: | I17RC_HUMAN |
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