The IL17RC Polyclonal Antibody (PACO09919) is a valuable tool for researchers studying IL17RC, a cell surface receptor involved in the regulation of the inflammatory cytokine IL-17. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By targeting the IL17RC protein, this antibody allows for the detection and analysis of IL17RC in various cell types, making it an ideal choice for research in immunology and inflammatory diseases.
IL17RC, also known as IL-17 receptor C, plays a crucial role in the immune response by mediating the effects of IL-17, a key player in inflammation and autoimmune diseases. Understanding the function of IL17RC is essential for uncovering its role in diseases like rheumatoid arthritis, psoriasis, and inflammatory bowel disease. By studying IL17RC, researchers can gain valuable insights into the mechanisms of inflammation and potentially develop new therapeutic strategies for managing inflammatory conditions.
IL17RC: a single-pass type I membrane protein that shares similarity with the interleukin-17 receptor (IL-17RA). Unlike IL-17RA, which is predominantly expressed in hemopoietic cells, and binds with high affinity to only IL-17A, this protein is expressed in nonhemopoietic tissues, and binds both IL-17A and IL-17F with similar affinities. The proinflammatory cytokines, IL-17A and IL-17F, have been implicated in the progression of inflammatory and autoimmune diseases. Multiple alternatively spliced transcript variants encoding different isoforms have been detected for this gene, and it has been proposed that soluble, secreted proteins lacking transmembrane and intracellular domains may function as extracellular antagonists to cytokine signaling. [provided by RefSeq, Feb 2011]Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 3p25.3|3p25.3-p24.1Cellular Component: integral to plasma membraneMolecular Function: interleukin-17 receptor activityBiological Process: cytokine and chemokine mediated signaling pathwayDisease: Candidiasis, Familial, 9
UniProt Protein Details:
NCBI Summary:
This gene encodes a single-pass type I membrane protein that shares similarity with the interleukin-17 receptor (IL-17RA). Unlike IL-17RA, which is predominantly expressed in hemopoietic cells, and binds with high affinity to only IL-17A, this protein is expressed in nonhemopoietic tissues, and binds both IL-17A and IL-17F with similar affinities. The proinflammatory cytokines, IL-17A and IL-17F, have been implicated in the progression of inflammatory and autoimmune diseases. Multiple alternatively spliced transcript variants encoding different isoforms have been detected for this gene, and it has been proposed that soluble, secreted proteins lacking transmembrane and intracellular domains may function as extracellular antagonists to cytokine signaling. [provided by RefSeq, Feb 2011]
