The IL17RB Polyclonal Antibody (CAB10147) is a key tool for researchers studying IL17RB, a receptor for the pro-inflammatory cytokine IL-17B. This antibody, generated in rabbits, is highly specific to human samples and has been validated for use in various applications, including Western blot and immunohistochemistry.IL17RB is known to play a role in the regulation of immune responses, particularly in inflammation and autoimmune diseases. By targeting IL17RB with this antibody, researchers can detect and analyze the expression of this receptor in different cell types, providing valuable insights into its function in various physiological and pathological conditions.
With its ability to facilitate the detection and characterization of IL17RB, this polyclonal antibody is an essential tool for studies in immunology, inflammation, and cancer research. By understanding the role of IL17RB in these contexts, researchers can potentially uncover new therapeutic targets and strategies for treating diseases associated with dysregulated immune responses.
Product Name:
IL17RB Rabbit Polyclonal Antibody
SKU:
CAB10147
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 18-292 of human IL17RB (NP_061195.2).
Cell membrane, Secreted, Single-pass type I membrane protein.
Calculated MW:
56kDa
Observed MW:
75kDa
The protein encoded by this gene is a cytokine receptor. This receptor specifically binds to IL17B and IL17E, but does not bind to IL17 and IL17C. This receptor has been shown to mediate the activation of NF-kappaB and the production of IL8 induced by IL17E. The expression of the rat counterpart of this gene was found to be significantly up-regulated during intestinal inflammation, which suggested the immunoregulatory activity of this receptor.
Purification Method:
Affinity purification
Gene ID:
55540
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using IL17RB antibody (CAB10147) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
