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IL17E Monoclonal Antibody [YR-hIL17E] (CPAB0012)

SKU:
CPAB0012
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG2a
Clone:
YR-hIL17E
Applications:
IP
ELISA
IHC
€660
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Description

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IL17E Monoclonal Antibody [YR-hIL17E] (CPAB0012)

The IL17E Antibody (CPAB0012) is a polyclonal antibody designed for research involving IL17E, a cytokine belonging to the IL-17 family known for its role in immune regulation and inflammation. Raised in rabbits, this antibody is highly specific to human samples and has been validated for use in various applications, including Western blotting.IL17E, also known as Interleukin-25, plays a critical role in the regulation of immune responses, particularly in the context of Th2-mediated inflammation. Its ability to modulate the activity of immune cells and promote tissue repair makes it a key target for research in immunology and inflammatory disorders.

This antibody binds specifically to IL17E, allowing for the accurate detection and analysis of this important cytokine in cell culture and tissue samples.With its potential implications in diseases such as asthma, allergic reactions, and inflammatory conditions, studying the role of IL17E can provide valuable insights into the underlying mechanisms of these disorders. The IL17E Antibody (CPAB0012) offers researchers a valuable tool for investigating the function of IL17E and its potential as a therapeutic target in various pathological conditions.

Product Name:IL17E Antibody
Product Sku:CPAB0012
Size:500μg
Host Species:mouse
Immunogen:r.Human IL-17E
Clone:YR-hIL17E.
Reactivity:Human
Applications:Immuneprecipitation, ELISA, Immunohistochemistry
Purification Method:Protein A
Isotype:IgG2a
Background:IL-25 also called IL-17E cytokine has a sequence similarity with IL17. IL-17E indluces NF-kappaB activation, and stimulates the production of IL-8. IL17E and IL17B are ligands for the cytokine receptor IL17BR. IL-25 is a proinflammatory cytokine favoring Th2-type immune response. The upregulation of costimulation-induced IL-17E receptors and release of cytokines and chemokines from IL-17E treated costimulated Th cells are differentially regulated by intracellular JNK, p38 MAPK and NF-kappaB activity. Blocking Iinterleukin-25 prevents airway hyperresponsiveness, a critical feature of clinical asthma. IL25 produced by innate effector eosinophils and basophils increase the allergic inflammation by enhancing the maintenance and functions of TSLP-DC activated adaptive Th2 memory cells. Over expression of IL-25 up-regulates gene expression of Th2 cytokines and induces growth retardation, jaundice, and multiorgan inflammation in a transgenic mouse model. IL-25 contributes to the induction and maintenance of eosinophilic inflammation by acting on lung fibroblasts which supports the fact that IL-17E is an important factor in asthma pathophysiology. IL-17E operates by amplifying TH2 cell-mediated allergic airway inflammation but doesn't induce allergic inflammation in vivo.
Synonyms:IL-25, IL-17E, IL17E, IL25, Interleukin-25.
Storage Buffer:In lyophilized form, for long periods, store at 4°C in a dry environment. After reconstitution, if not intended for use within a month, aliquot and store at -20°C.

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