The IL17A Polyclonal Antibody (CAB12454) is a valuable tool for researchers studying IL17A, a pro-inflammatory cytokine known for its role in immune responses and inflammatory conditions. This antibody is produced in rabbits and has been validated for Western blot applications, allowing for the detection and analysis of IL17A protein in various types of samples.IL17A is a key player in the regulation of inflammation and has been implicated in various diseases, including autoimmune disorders, inflammatory bowel disease, and rheumatoid arthritis.
By targeting IL17A, researchers can gain insight into the mechanisms underlying these conditions and develop potential therapeutic strategies.This highly reactive antibody binds specifically to IL17A, making it an ideal choice for studies focusing on immunology, inflammation, and related fields. Its ability to accurately detect and quantify IL17A protein levels in samples from different sources makes it a valuable tool for advancing our understanding of immune responses and developing targeted treatments for inflammatory diseases.
Product Name:
IL17A Rabbit Polyclonal Antibody
SKU:
CAB12454
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human IL17A (NP_002181.1).
This gene is a member of the IL-17 receptor family which includes five members (IL-17RA-E) and the encoded protein is a proinflammatory cytokine produced by activated T cells. IL-17A-mediated downstream pathways induce the production of inflammatory molecules, chemokines, antimicrobial peptides, and remodeling proteins. The encoded protein elicits crucial impacts on host defense, cell trafficking, immune modulation, and tissue repair, with a key role in the induction of innate immune defenses. This cytokine stimulates non-hematopoietic cells and promotes chemokine production thereby attracting myeloid cells to inflammatory sites. This cytokine also regulates the activities of NF-kappaB and mitogen-activated protein kinases and can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). IL-17A plays a pivotal role in various infectious diseases, inflammatory and autoimmune disorders, and cancer. High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. The lung damage induced by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is to a large extent, a result of the inflammatory response promoted by cytokines such as IL17A.
Purification Method:
Affinity purification
Gene ID:
3605
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates, using IL17A Rabbit pAb (CAB12454) at 1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
