The IL17A Monoclonal Antibody (CAB21266) is a crucial tool for researchers studying IL17A, a pro-inflammatory cytokine involved in various immune responses. This antibody, produced using monoclonal technology, specifically targets IL17A in human samples and has been validated for use in applications such as Western blot and immunohistochemistry.IL17A, also known as interleukin 17A, is a key mediator of inflammation and plays a significant role in autoimmune diseases, chronic inflammatory conditions, and host defense against pathogens.
By targeting IL17A, researchers can better understand its function and potential therapeutic implications in these disease contexts.The IL17A Monoclonal Antibody enables precise detection and analysis of IL17A in various cell types, providing valuable insights for immunology and disease research. Its high specificity and sensitivity make it an essential tool for studies aiming to uncover the mechanisms underlying IL17A-mediated immune responses and potential therapeutic interventions.
Product Name:
IL17A Monoclonal Antibody
SKU:
CAB21266
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 24-155 of human IL17A (NP_002181.1).
This gene is a member of the IL-17 receptor family which includes five members (IL-17RA-E) and the encoded protein is a proinflammatory cytokine produced by activated T cells. IL-17A-mediated downstream pathways induce the production of inflammatory molecules, chemokines, antimicrobial peptides, and remodeling proteins. The encoded protein elicits crucial impacts on host defense, cell trafficking, immune modulation, and tissue repair, with a key role in the induction of innate immune defenses. This cytokine stimulates non-hematopoietic cells and promotes chemokine production thereby attracting myeloid cells to inflammatory sites. This cytokine also regulates the activities of NF-kappaB and mitogen-activated protein kinases and can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). IL-17A plays a pivotal role in various infectious diseases, inflammatory and autoimmune disorders, and cancer. High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. The lung damage induced by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is to a large extent, a result of the inflammatory response promoted by cytokines such as IL17A.
Purification Method:
Affinity purification
Gene ID:
3605
Clone Number:
ARC52762
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Immunohistochemistry analysis of paraffin-embedded human colon carcinoma using IL17A Rabbit mAb (CAB21266) at dilution of 1:100(40x lens).Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.
