The IL15 Polyclonal Antibody is a powerful tool for research involving IL15, a cytokine involved in the regulation of immune responses and the proliferation of T and natural killer cells. This antibody, generated in rabbits, is highly specific to IL15 and has been validated for use in a variety of applications, including Western blot and immunohistochemistry.IL15 plays a crucial role in the immune system, promoting the activation and survival of various immune cells. Dysregulation of IL15 has been implicated in inflammatory and autoimmune diseases, as well as in the development of certain types of cancer.
By targeting IL15 with this antibody, researchers can gain valuable insights into the role of this cytokine in health and disease.The IL15 Polyclonal Antibody is a valuable tool for studying the functions of IL15 in different cell types and tissues, making it ideal for research in immunology, oncology, and inflammatory disorders. Its high specificity and sensitivity make it a reliable choice for researchers looking to explore the complexities of immune regulation and potential therapeutic targets.
Product Name:
IL15 Polyclonal Antibody
SKU:
CAB24510
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 49-162 of human IL15 (NP_000576.1).
The protein encoded by this gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. Alternatively spliced transcript variants of this gene have been reported.
Purification Method:
Affinity purification
Gene ID:
3600
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of Mouse heart, using IL15 Rabbit pAb (CAB24510) at 1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
