The IL13 Polyclonal Antibody (CAB12453) is a valuable tool for researchers studying interleukin-13 (IL-13), a cytokine with diverse functions in immune responses and inflammation. This antibody, generated in rabbits, exhibits strong reactivity with human samples and has been validated for use in Western blotting applications. By specifically targeting the IL-13 protein, researchers can accurately detect and analyze its expression in a variety of cell types, making it an excellent choice for studies in immunology, allergy, and asthma research.IL-13 is known for its role in promoting allergic responses and contributing to the pathogenesis of allergic diseases such as asthma. Additionally, IL-13 has been implicated in the regulation of immune cell functions and inflammation, making it a promising target for therapeutic interventions in inflammatory conditions and autoimmune disorders.
By studying the mechanisms of IL-13 activity, researchers can gain valuable insights into disease processes and potentially identify new treatment strategies aimed at modulating immune responses.Overall, the IL13 Polyclonal Antibody is a powerful tool for investigating the complex functions of interleukin-13 in the immune system and related diseases. Its high specificity and sensitivity make it an essential reagent for researchers seeking to unravel the roles of IL-13 in health and disease.
Product Name:
IL13 Rabbit Polyclonal Antibody
SKU:
CAB12453
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 25-146 of human IL13 (NP_002179.2).
This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4.
Purification Method:
Affinity purification
Gene ID:
3596
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using IL13 antibody (CAB12453) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 90s.
