The IL12RB2 Polyclonal Antibody (CAB10348) is a valuable tool for researchers studying the IL12RB2 protein, a key component of the interleukin 12 receptor complex involved in immune responses. This antibody, generated in rabbits, exhibits high specificity and sensitivity towards human samples, making it suitable for various applications, including Western blotting.IL12RB2 is essential for signaling pathways that regulate inflammation and immunity, making it a crucial target in research related to infectious diseases, autoimmune disorders, and cancer.
By detecting and analyzing IL12RB2 protein levels in different cell types, this antibody enables researchers to gain insights into the role of IL12RB2 in these disease processes.Overall, the IL12RB2 Polyclonal Antibody provides researchers with a powerful tool for investigating the function and regulation of IL12RB2, ultimately contributing to the development of targeted therapies and treatments for immune-related disorders.
Product Name:
IL12RB2 Rabbit Polyclonal Antibody
SKU:
CAB10348
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 420-620 of human IL12RB2 (NP_001550.1).
The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense. Several transcript variants encoding different isoforms and non-protein coding transcripts have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
3595
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using IL12RB2 antibody (CAB10348) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
