The IL12RB1 Polyclonal Antibody (CAB1886) is a powerful tool for researchers studying the IL12RB1 protein, a critical component in the interleukin-12 signaling pathway. This antibody, produced in rabbits, exhibits high reactivity specifically with human samples and has been validated for use in Western blot applications. By binding to IL12RB1, this antibody enables precise detection and analysis of the protein in different cell types, making it ideal for investigations in immunology and cancer research.IL12RB1 is essential for mediating the effects of interleukin-12, a cytokine involved in regulating immune responses and promoting the development of T cells.
Dysregulation of the IL12RB1 pathway has been implicated in various diseases, including autoimmune disorders and cancer. Researchers studying these conditions rely on antibodies like CAB1886 to gain insights into the role of IL12RB1 in immune function and disease progression.By using the IL12RB1 Polyclonal Antibody (CAB1886), researchers can advance their understanding of the interleukin-12 pathway and its impact on immune system regulation. This antibody is a valuable tool for uncovering new therapeutic targets and developing innovative treatment strategies for immune-related disorders.
Product Name:
IL12RB1 Rabbit Polyclonal Antibody
SKU:
CAB1886
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 25-305 of human IL12RB1 (NP_714912.1).
The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. Mutations in this gene impair the development of interleukin-17-producing T lymphocytes and result in increased susceptibility to mycobacterial and Salmonella infections. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
3594
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates, using IL12RB1 Rabbit pAb (CAB1886) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
