IL12B Rabbit Polyclonal Antibody (CAB13024)
- SKU:
- CAB13024
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | IL12B Rabbit Polyclonal Antibody |
SKU: | CAB13024 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 23-328 of human IL12B (NP_002178.2). |
Sequence: | IWEL KKDV YVVE LDWY PDAP GEMV VLTC DTPE EDGI TWTL DQSS EVLG SGKT LTIQ VKEF GDAG QYTC HKGG EVLS HSLL LLHK KEDG IWST DILK DQKE PKNK TFLR CEAK NYSG RFTC WWLT TIST DLTF SVKS SRGS SDPQ GVTC GAAT LSAE RVRG DNKE YEYS VECQ EDSA CPAA EESL PIEV MVDA VHKL KYEN YTSS FFIR DIIK PDPP KNLQ LKPL KNSR QVEV SWEY PDTW STPH SYFS LTFC VQVQ GKSK REKK DRVF TDKT SATV ICRK NASI SVRA QDRY YSSS WSEW ASVP CS |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:1000 - 1:2000 |
Synonyms: | CLMF; NKSF; CLMF2; IMD28; IMD29; NKSF2; IL-12B; IL12B |
Positive Sample: | A-549,HeLa |
Conjugate: | Unconjugated |
Cellular Localization: | Secreted. |
Calculated MW: | 37kDa |
Observed MW: | 37kDa |
This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children.
Purification Method: | Affinity purification |
Gene ID: | 3593 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |