The IL12B Polyclonal Antibody (PAC027585) is a valuable tool for researchers studying the IL12B protein, a cytokine involved in immune regulation and inflammatory responses. This antibody, produced in rabbits, has high reactivity with human samples and is validated for use in Western blot applications. By binding to IL12B, it allows for the detection and analysis of this important protein in a variety of cell types, making it an ideal choice for studies in immunology and inflammatory diseases.IL12B, also known as interleukin-12 subunit beta, is a key player in the immune system, promoting the production of interferon-gamma and enhancing the activity of natural killer cells and T cells.
Dysregulation of IL12B has been linked to various inflammatory conditions, autoimmune diseases, and cancer. By understanding the role of IL12B in these diseases, researchers can develop targeted therapies to modulate immune responses and potentially treat or prevent these conditions.Overall, the IL12B Polyclonal Antibody is a valuable tool for researchers seeking to delve deeper into the complex workings of the immune system and the role of cytokines like IL12B in maintaining immune homeostasis and responding to threats.
Antibody Name:
IL12B Antibody (PACO27585)
Antibody SKU:
PACO27585
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA
Recommended Dilutions:
Species Reactivity:
Sheep
Immunogen:
Recombinant Sheep Interleukin-12 subunit β protein (23-327AA)
Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-γ by resting PBMC By similarity.Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis By similarity.
