The IL11RA Polyclonal Antibody (CAB6627) is a valuable tool for researchers studying the IL11RA protein, a receptor for interleukin-11 involved in various cellular processes, such as cell growth and differentiation. This antibody is produced in rabbits and has high specificity for human samples, making it ideal for use in Western blot applications. By binding to the IL11RA protein, this antibody enables researchers to detect and analyze its expression in different cell types.IL11RA plays a crucial role in mediating the effects of interleukin-11, a cytokine that regulates hematopoiesis, bone metabolism, and inflammation. Dysregulation of IL11RA signaling has been linked to various diseases, including cancer, osteoporosis, and inflammatory disorders.
Therefore, studying the expression and function of IL11RA using this polyclonal antibody is essential for further understanding its role in these pathological conditions.By utilizing the IL11RA Polyclonal Antibody (CAB6627), researchers can gain insights into the regulatory mechanisms of IL11RA and its potential as a therapeutic target for diseases associated with aberrant interleukin-11 signaling. This antibody is a valuable tool for investigations in immunology, oncology, and other fields where IL11RA signaling is of interest.
Product Name:
IL11RA Rabbit Polyclonal Antibody
SKU:
CAB6627
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 30-290 of human IL11RA (NP_001136256.1).
Interleukin 11 is a stromal cell-derived cytokine that belongs to a family of pleiotropic and redundant cytokines that use the gp130 transducing subunit in their high affinity receptors. This gene encodes the IL-11 receptor, which is a member of the hematopoietic cytokine receptor family. This particular receptor is very similar to ciliary neurotrophic factor, since both contain an extracellular region with a 2-domain structure composed of an immunoglobulin-like domain and a cytokine receptor-like domain. Multiple alternatively spliced transcript variants have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
3590
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using IL11RA Antibody (CAB6627) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
