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Anti-IL-10RB Antibody (CAB15680)

SKU:
CAB15680
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Immunology
  • Immunology Antibodies 2 Anti-IL-10RB Antibody CAB15680
  • Immunology Antibodies 2 Anti-IL-10RB Antibody CAB15680
€139 - €419
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Description

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Anti-IL-10RB Antibody (CAB15680)

The IL10RB Polyclonal Antibody (CAB15680) is a valuable tool for researchers studying IL10RB, a receptor for the anti-inflammatory cytokine interleukin 10 (IL-10). This antibody, generated in rabbits, has high specificity and sensitivity for detecting IL10RB in human samples, making it suitable for use in Western blot and immunohistochemistry applications.IL10RB plays a crucial role in mediating the anti-inflammatory effects of IL-10, serving as a key component in the regulation of immune responses and inflammation. Dysregulation of the IL-10 signaling pathway has been implicated in various immune-related disorders, including autoimmune diseases and inflammatory conditions.

By using the IL10RB Polyclonal Antibody, researchers can investigate the expression and function of IL10RB in different cell types and tissues, providing insights into the role of this receptor in health and disease. This antibody is a valuable tool for studies in immunology, inflammation, and cytokine signaling pathways, offering important implications for the development of novel therapeutic strategies targeting IL10RB.

Antibody Name:IL10RB Rabbit Polyclonal Antibody
Antibody SKU:CAB15680
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 20-220 of human IL10RB (NP_000619.3).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:U-87MG, 293T, Jurkat, mouse skeletal muscle, rat heart, rat liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 20-220 of human IL10RB (NP_000619.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MVPP PENV RMNS VNFK NILQ WESP AFAK GNLT FTAQ YLSY RIFQ DKCM NTTL TECD FSSL SKYG DHTL RVRA EFAD EHSD WVNI TFCP VDDT IIGP PGMQ VEVL ADSL HMRF LAPK IENE YETW TMKN VYNS WTYN VQYW KNGT DEKF QITP QYDF EVLR NLEP WTTY CVQV RGFL PDRN KAGE WSEP VCEQ TTHD ETVP S
Gene ID:3588
Uniprot:Q08334
Cellular Location:Membrane, Single-pass type I membrane protein
Calculated MW:36kDa
Observed MW:36kDa
Synonyms:IL10RB, CDW210B, CRF2-4, CRFB4, D21S58, D21S66, IL-10R2
Background:The protein encoded by this gene belongs to the cytokine receptor family. It is an accessory chain essential for the active interleukin 10 receptor complex. Coexpression of this and IL10RA proteins has been shown to be required for IL10-induced signal transduction. This gene and three other interferon receptor genes, IFAR2, IFNAR1, and IFNGR2, form a class II cytokine receptor gene cluster located in a small region on chromosome 21.
UniProt Protein Function:Shared cell surface receptor required for the activation of five class 2 cytokines: IL10, IL22, IL26, IL28, and IFNL1. The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state.
NCBI Summary:The protein encoded by this gene belongs to the cytokine receptor family. It is an accessory chain essential for the active interleukin 10 receptor complex. Coexpression of this and IL10RA proteins has been shown to be required for IL10-induced signal transduction. This gene and three other interferon receptor genes, IFAR2, IFNAR1, and IFNGR2, form a class II cytokine receptor gene cluster located in a small region on chromosome 21. [provided by RefSeq, Jul 2008]
UniProt Code:Q08334
NCBI GenInfo Identifier:56757647
NCBI Gene ID:3588
NCBI Accession:Q08334.2
UniProt Secondary Accession:Q08334,Q9BUU4,
UniProt Related Accession:Q08334
Molecular Weight:36,995 Da
NCBI Full Name:Interleukin-10 receptor subunit beta
NCBI Synonym Full Names:interleukin 10 receptor subunit beta
NCBI Official Symbol:IL10RB  
NCBI Official Synonym Symbols:CRFB4; CRF2-4; D21S58; D21S66; CDW210B; IL-10R2  
NCBI Protein Information:interleukin-10 receptor subunit beta
UniProt Protein Name:Interleukin-10 receptor subunit beta
UniProt Synonym Protein Names:Cytokine receptor class-II member 4; Cytokine receptor family 2 member 4; CRF2-4; Interleukin-10 receptor subunit 2; IL-10R subunit 2; IL-10R2; CD_antigen: CDw210b
Protein Family:Interleukin-10 receptor
UniProt Gene Name:IL10RB  
Anti-IL-10RB Antibody (CAB15680)Western blot analysis of extracts of various cell lines, using IL10RB antibody (CAB15680) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
Anti-IL-10RB Antibody (CAB15680)Immunofluorescence analysis of L929 cells using IL10RB antibody (CAB15680) at dilution of 1:100. Blue: DAPI for nuclear staining.

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