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IKZF4 Transcription Factor Activity Assay

SKU:
TFAB00203
Product Type:
ELISA Kit
ELISA Type:
Transcription Factor Assay
Analytes:
IKZF4
Reactivity:
Human
Mouse
Rat
€599
Frequently bought together:

Description

system_update_altDatasheet

IKZF4 Transcription Factor Activity Assay

The IKZF4 Transcription Factor Activity Assay provided by AssayGenie is a cutting-edge kit designed for accurate measurement of IKZF4 transcription factor activity in cell lysates. This assay kit offers high sensitivity and specificity, ensuring precise and reliable results for research applications.IKZF4, also known as Ikaros Family Zinc Finger 4, plays a crucial role in regulating gene expression and is involved in various cellular processes such as immune response, hematopoiesis, and differentiation. Dysregulation of IKZF4 has been linked to several diseases including leukemia, autoimmune disorders, and inflammatory conditions, making it a valuable target for research and drug development.

With the IKZF4 Transcription Factor Activity Assay, researchers can assess IKZF4 activity in a simple and efficient manner, allowing for in-depth analysis of its role in disease pathogenesis and potential therapeutic interventions. Trust AssayGenie for high-quality assays that enable groundbreaking discoveries in the field of molecular biology.

Product Name:IKZF4 Transcription Factor Activity Assay
Product Code:TFAB00203
Target:IKZF4
Reactivity:Human, Mouse, Rat
Sample Types:Nuclear or cell lysates

The Assay Genie IKZF4 transcription factor activity assay allows for the detection and qualitative analysis of endogenous levels of activated transcription factors in a variety of nuclear and cell lysates

Assay Genie ELISA kits are designed to significantly reduce experiment time and ensure sensitivity and flexibility for high-throughput screening.

Assay Time:4.5 hours
Detection Method:Colorimetric 450 nm
Size:12 x 8-Well Microstrips
Storage:4°C for 6 months
UniProt Protein Function:IKZF4: DNA-binding protein that binds to the 5'GGGAATRCC-3' Ikaros-binding sequence. Transcriptional repressor. Interacts with SPI1 and MITF to repress transcription of the CTSK and ACP5 promoters via recruitment of corepressors SIN3A and CTBP2. May be involved in the development of central and peripheral nervous systems. Belongs to the Ikaros C2H2-type zinc-finger protein family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:C2H2-type zinc finger protein; Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 12q13

Cellular Component: nucleus

Molecular Function:protein homodimerization activity; sequence-specific DNA binding; protein heterodimerization activity; metal ion binding; bHLH transcription factor binding; transcription factor activity

Biological Process: transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent

NCBI Summary:Members of the Ikaros (ZNFN1A1; MIM 603023) family of transcription factors, which includes Eos, are expressed in lymphocytes and are implicated in the control of lymphoid development.[supplied by OMIM, Jul 2002]
UniProt Code:Q9H2S9
NCBI GenInfo Identifier:122891864
NCBI Gene ID:64375
NCBI Accession:NP_071910.3
UniProt Related Accession:Q9H2S9
Molecular Weight:
NCBI Full Name:zinc finger protein Eos isoform a
NCBI Synonym Full Names:IKAROS family zinc finger 4
NCBI Official Symbol:IKZF4  
NCBI Official Synonym Symbols:EOS; ZNFN1A4  
NCBI Protein Information:zinc finger protein Eos
UniProt Protein Name:Zinc finger protein Eos
UniProt Synonym Protein Names:Ikaros family zinc finger protein 4
Protein Family:Eosinophil peroxidase
UniProt Gene Name:IKZF4  
UniProt Entry Name:IKZF4_HUMAN
Antibodies
IKZF4 Antibody (PACO05030)
IKZF4 Antibody (PACO20958)
IKZF4 Antibody (PACO20959)

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