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IKZF4 Antibody (PACO05030)

SKU:
PACO05030
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€269
Frequently bought together:

Description

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IKZF4 Antibody (PACO05030)

The IKZF4 Polyclonal Antibody (PACO05030) is a valuable tool for researchers studying IKZF4, a key transcription factor involved in immune cell development and function. This antibody, raised in rabbits, has a high affinity for human samples and is validated for use in Western blot applications. By specifically binding to the IKZF4 protein, researchers can detect and analyze its expression in various cell types, making it ideal for studies in immunology and cancer research.IKZF4, also known as Eos, plays a crucial role in the regulation of immune responses by controlling the differentiation and function of immune cells.

Its involvement in immune cell development and function makes IKZF4 a promising target for investigating diseases such as cancer, autoimmune disorders, and inflammatory conditions. By understanding the role of IKZF4 in immune regulation, researchers can potentially develop novel therapeutic strategies to modulate immune responses in disease states.

Antibody Name:IKZF4 Antibody (PACO05030)
Antibody SKU:PACO05030
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB
Recommended Dilutions:ELISA:1:40000, WB:1:500-1:2000
Species Reactivity:Human, Mouse, Rat
Immunogen:Synthesized peptide derived from the C-terminal region of human Eos.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:IKZF4; KIAA1782; ZNFN1A4; Zinc finger protein Eos; Ikaros family zinc finger protein 4
UniProt Protein Function:IKZF4: DNA-binding protein that binds to the 5'GGGAATRCC-3' Ikaros-binding sequence. Transcriptional repressor. Interacts with SPI1 and MITF to repress transcription of the CTSK and ACP5 promoters via recruitment of corepressors SIN3A and CTBP2. May be involved in the development of central and peripheral nervous systems. Belongs to the Ikaros C2H2-type zinc-finger protein family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:C2H2-type zinc finger protein; Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 12q13

Cellular Component: nucleus

Molecular Function:protein homodimerization activity; sequence-specific DNA binding; protein heterodimerization activity; metal ion binding; bHLH transcription factor binding; transcription factor activity

Biological Process: transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent

NCBI Summary:Members of the Ikaros (ZNFN1A1; MIM 603023) family of transcription factors, which includes Eos, are expressed in lymphocytes and are implicated in the control of lymphoid development.[supplied by OMIM, Jul 2002]
UniProt Code:Q9H2S9
NCBI GenInfo Identifier:122891864
NCBI Gene ID:64375
NCBI Accession:NP_071910.3
UniProt Related Accession:Q9H2S9
Molecular Weight:
NCBI Full Name:zinc finger protein Eos isoform a
NCBI Synonym Full Names:IKAROS family zinc finger 4
NCBI Official Symbol:IKZF4  
NCBI Official Synonym Symbols:EOS; ZNFN1A4  
NCBI Protein Information:zinc finger protein Eos
UniProt Protein Name:Zinc finger protein Eos
UniProt Synonym Protein Names:Ikaros family zinc finger protein 4
Protein Family:Eosinophil peroxidase
UniProt Gene Name:IKZF4  
UniProt Entry Name:IKZF4_HUMAN

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