The IKZF3 Polyclonal Antibody (CAB7287) is a valuable tool for researchers studying the IKZF3 protein, also known as Aiolos, a transcription factor involved in immune response regulation. This antibody, produced in rabbits, exhibits high specificity and sensitivity in detecting IKZF3 in human samples, making it suitable for use in various experimental techniques such as Western blotting.IKZF3 is a key player in the development and function of immune cells, particularly in the regulation of B cell differentiation and maturation.
Dysregulation of IKZF3 has been implicated in autoimmune diseases, leukemia, and other immune-related disorders, highlighting its potential as a therapeutic target. By utilizing the IKZF3 Polyclonal Antibody, researchers can explore the molecular mechanisms underlying IKZF3's role in health and disease, paving the way for new insights and potential therapeutic interventions.
Product Name:
IKZF3 Rabbit Polyclonal Antibody
SKU:
CAB7287
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 280-450 of human IKZF3 (NP_036613.2).
This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. Several alternative transcripts encoding different isoforms have been described, as well as some non-protein coding variants.
Purification Method:
Affinity purification
Gene ID:
22806
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using IKZF3 Antibody (CAB7287) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
