The IKK Polyclonal Antibody is a valuable tool for researchers studying IKK, a key signaling molecule involved in regulating inflammation and immune responses. This antibody, produced in rabbits, is highly specific for human samples and is validated for use in Western blot applications.IKK, also known as IκB kinase, plays a critical role in the activation of NF-κB, a transcription factor involved in the expression of genes related to inflammation, immune responses, and cell survival. Dysregulation of the NF-κB signaling pathway has been implicated in various diseases, including cancer, inflammatory disorders, and autoimmune conditions.
By targeting IKK with this polyclonal antibody, researchers can better understand the role of this kinase in disease development and progression. This antibody enables detection and analysis of IKK in various cell types, providing valuable insights for studies in immunology, oncology, and inflammatory diseases.Overall, the IKK Polyclonal Antibody is a reliable tool for investigating the molecular mechanisms underlying inflammation and immune responses, with the potential to uncover new therapeutic targets for a range of debilitating conditions.
Product Name:
IKKα Polyclonal Antibody
SKU:
CAB21354
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 600-700 of human IKKα (NP_001269.3).
This gene encodes a member of the serine/threonine protein kinase family. The encoded protein, a component of a cytokine-activated protein complex that is an inhibitor of the essential transcription factor NF-kappa-B complex, phosphorylates sites that trigger the degradation of the inhibitor via the ubiquination pathway, thereby activating the transcription factor.
Purification Method:
Affinity purification
Gene ID:
1147
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from Jurkat cells using [KO Validated] IKKα Rabbit pAb(CAB21354) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25 μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 180s.
