The IKK Monoclonal Antibody is a specialized tool for researchers studying the IKK protein, a key regulator of the NF-κB signaling pathway involved in various cellular processes, including inflammation, immune response, and cell survival. This antibody, produced in a mouse model, shows high specificity and sensitivity in detecting IKK in human samples, making it suitable for Western blot applications.IKK, also known as IκB kinase, plays a crucial role in the activation of NF-κB, a transcription factor involved in the expression of genes relevant to immune and inflammatory responses.
Dysregulation of the NF-κB pathway is associated with various diseases, including cancer, inflammatory disorders, and autoimmune conditions. By targeting IKK and understanding its function, researchers can gain insight into the molecular mechanisms underlying these pathological conditions and potentially identify new therapeutic targets. Overall, the IKK Monoclonal Antibody is a valuable tool for researchers exploring the role of IKK in health and disease, providing reliable and accurate detection for in-depth studies in immunology, cancer biology, and inflammatory pathways.
Product Name:
IKKβ Monoclonal Antibody
SKU:
CAB22425
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human IKKβ (O14920).
The protein encoded by this gene phosphorylates the inhibitor in the inhibitor/NF-kappa-B complex, causing dissociation of the inhibitor and activation of NF-kappa-B. The encoded protein itself is found in a complex of proteins. Several transcript variants, some protein-coding and some not, have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
3551
Clone Number:
ARC0085
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using IKKβ Rabbit mAb (CAB22425) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
