The IKBKG Polyclonal Antibody (CAB0917) is a valuable tool for researchers studying IKBKG, a key regulator in the NF-κB signaling pathway involved in immune and inflammatory responses. This rabbit-raised antibody is highly specific for human samples and has been validated for use in Western blot applications, enabling detection and analysis of IKBKG protein levels in a variety of cell types.IKBKG, also known as NEMO (NF-κB Essential Modulator), is crucial for the activation of NF-κB transcription factors, which play a central role in immune responses, inflammation, and cell survival. Dysregulation of the NF-κB pathway is associated with various diseases, including cancer, inflammatory disorders, and autoimmune conditions.
By targeting IKBKG, researchers can gain insights into the molecular mechanisms underlying these diseases and identify potential therapeutic targets for drug development.With its high specificity and sensitivity, the IKBKG Polyclonal Antibody (CAB0917) is an essential tool for researchers investigating the role of IKBKG in immune regulation and inflammatory pathways. By accurately detecting and measuring IKBKG protein expression, this antibody facilitates in-depth studies in immunology, oncology, and other fields related to immune system function and disease pathology.
Product Name:
IKKγ Rabbit Polyclonal Antibody
SKU:
CAB0917
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 250-390 of human IKKγ (NP_003630.1).
Sequence:
VGSE RKRG MQLE DLKQ QLQQ AEEA LVAK QEVI DKLK EEAE QHKI VMET VPVL KAQA DIYK ADFQ AERQ AREK LAEK KELL QEQL EQLQ REYS KLKA SCQE SARI EDMR KRHV EVSQ APLP PAPA YLSS PLAL PSQR RSPP E
This gene encodes the regulatory subunit of the inhibitor of kappaB kinase (IKK) complex, which activates NF-kappaB resulting in activation of genes involved in inflammation, immunity, cell survival, and other pathways. Mutations in this gene result in incontinentia pigmenti, hypohidrotic ectodermal dysplasia, and several other types of immunodeficiencies. A pseudogene highly similar to this locus is located in an adjacent region of the X chromosome.
Purification Method:
Affinity purification
Gene ID:
8517
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using IKKγ Rabbit pAb (CAB0917) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3s.
