The IKBKE Polyclonal Antibody (CAB14093) is specifically designed for research involving IKBKE, a key protein in the NF-kappa-B signaling pathway that plays a crucial role in immune response and inflammation. The antibody, raised in rabbits, is highly reactive with human samples and is validated for use in various applications such as Western blot and immunohistochemistry.IKBKE, also known as IKKε, is a serine/threonine kinase that plays a significant role in activating NF-kappa-B transcription factors, which are involved in the regulation of immune and inflammatory responses.
Dysregulation of IKBKE has been linked to various diseases, including cancer, autoimmune disorders, and inflammatory conditions. Therefore, studying the function and expression of IKBKE using this antibody can provide valuable insights into the molecular mechanisms underlying these diseases.Overall, the IKBKE Polyclonal Antibody (CAB14093) is a valuable tool for researchers conducting studies in immunology, cancer research, and inflammatory diseases, providing reliable detection and analysis of IKBKE expression in different cell types and tissues.
Product Name:
IKKε Rabbit Polyclonal Antibody
SKU:
CAB14093
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 495-716 of human IKKε (NP_054721.1).
IKBKE is a noncanonical I-kappa-B (see MIM 164008) kinase (IKK) that is essential for regulating antiviral signaling pathways. IKBKE has also been identified as a breast cancer (MIM 114480) oncogene and is amplified and overexpressed in over 30% of breast carcinomas and breast cancer cell lines (Hutti et al., 2009 [PubMed 19481526]).
Purification Method:
Affinity purification
Gene ID:
9641
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using IKKε Rabbit pAb (CAB14093) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
