The IKBKE Polyclonal Antibody (CAB0244) is a valuable tool for researchers studying IKBKE, a key kinase involved in signaling pathways related to immune response and inflammation. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the IKBKE protein, this antibody enables accurate detection and analysis in various cell types, making it an ideal choice for studies in immunology and cancer research.IKBKE, also known as inhibitor of nuclear factor kappa B kinase subunit epsilon, plays a crucial role in regulating the activation of NF-κB and other transcription factors involved in inflammation and immune response.
Its involvement in these pathways makes it a promising target for research into various diseases, including cancer and autoimmune disorders. Understanding the function of IKBKE is essential for developing targeted therapies that manipulate immune responses in disease settings.
Product Name:
IKKε Rabbit Polyclonal Antibody
SKU:
CAB0244
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 497-716 of human IKKε (NP_054721.1).
IKBKE is a noncanonical I-kappa-B (see MIM 164008) kinase (IKK) that is essential for regulating antiviral signaling pathways. IKBKE has also been identified as a breast cancer (MIM 114480) oncogene and is amplified and overexpressed in over 30% of breast carcinomas and breast cancer cell lines (Hutti et al., 2009 [PubMed 19481526]).
Purification Method:
Affinity purification
Gene ID:
9641
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using IKKε Rabbit pAb (CAB0244) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates / proteins: 25 μg per lane.Blocking buffer: 3 % nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
