The IKBKAP Polyclonal Antibody (CAB10127) is a valuable tool for researchers studying IKBKAP, a gene involved in the regulation of immune and inflammatory responses. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding to the IKBKAP protein, this antibody enables the detection and analysis of IKBKAP in various cell types, making it ideal for investigations in immunology and inflammation-related research.IKBKAP, also known as inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein, plays a crucial role in the NF-kappa-B signaling pathway, which is involved in the regulation of immune and inflammatory responses.
Dysregulation of the NF-kappa-B pathway has been linked to various diseases, including cancer and inflammatory disorders, making IKBKAP a promising target for therapeutic development.By further exploring the function and regulation of IKBKAP, researchers can gain valuable insights into the underlying mechanisms of immune and inflammatory diseases, paving the way for the development of novel treatment strategies targeting the NF-kappa-B pathway. The IKBKAP Polyclonal Antibody (CAB10127) offers a reliable tool for such studies, enabling precise detection and analysis of IKBKAP expression levels in experimental settings.
Product Name:
IKBKAP Rabbit Polyclonal Antibody
SKU:
CAB10127
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1093-1332 of human IKBKAP (NP_003631.2).
The protein encoded by this gene is a scaffold protein and a regulator for three different kinases involved in proinflammatory signaling. The encoded protein can bind NF-kappa-B-inducing kinase and I-kappa-B kinases through separate domains and assemble them into an active kinase complex. Mutations in this gene have been associated with familial dysautonomia. Alternative splicing results in multiple transcript variants encoding different isoforms.
Purification Method:
Affinity purification
Gene ID:
8518
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using IKBKAP Rabbit pAb (CAB10127) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
