The IKBalpha Rabbit Polyclonal Antibody (CAB16929) is a research tool designed for investigating IKBalpha, a key regulator of the NF-kB signaling pathway involved in inflammation and immune responses. This antibody, raised in rabbits, has high specificity for human samples and is validated for use in Western blot applications. By binding to the IKBalpha protein, researchers can accurately detect and analyze its expression in various cell types, making it a valuable tool for studies in immunology and cancer research.IKBalpha is a critical protein that acts as a repressor of NF-kB, a transcription factor that regulates the expression of genes involved in inflammation, immunity, and cell survival.
Dysregulation of the NF-kB pathway is linked to various diseases, including cancer, inflammatory disorders, and autoimmune conditions. Understanding the role of IKBalpha in this pathway is essential for developing targeted therapies that modulate immune responses and inflammation in disease settings.Overall, the IKBalpha Rabbit Polyclonal Antibody (CAB16929) is a valuable tool for researchers seeking to explore the intricate mechanisms of the NF-kB signaling pathway and its implications in disease pathology. Its high specificity and reliability make it an excellent choice for studies aiming to decipher the complex interactions of IKBalpha in immune regulation and inflammatory responses.
Product Name:
IκBα Rabbit Polyclonal Antibody
SKU:
CAB16929
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 166-265 of human IκBα (NP_065390.1).
This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease.
Purification Method:
Affinity purification
Gene ID:
4792
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using IκBα antibody (CAB16929) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
